UK researchers say they have genetically engineered a zebrafish to produce a fluorescent green glow under a special microscope in response to exposure to endocrine-disrupting chemicals, a technique that could provide new
insights into how these chemicals penetrate and impact systems within the human body. After inserting genetic markers designed to produce a fluorescent glow within areas affected by the chemicals, the scientists from the University of Exeter exposed young fish to different levels of known endocrine disruptors — including bisphenol A, or BPA, a synthetic chemical found in thousands of everyday products, and ethinyloestradiol, a chemical found in contraceptive pills. According to their findings, published in the journal Environmental Health Perspectives, the researchers were able to determine in real-time how different parts of the fish’s anatomy — including the liver, testes, ovaries, and brain — were lit up by the endocrine-disrupting chemicals.
University of Exeter